Ritidosis

Ritidosis

Ritidosis es el término médico para denominar la presencia de arrugas en piel, así como pérdida de la tersura, teniendo variabilidad en la presentación, pero su mayor incidencia es iniciando por la región peribucal y continuando en región periorbitaria, formando las denominadas patas de gallo, progresivamente extendiéndose al resto de la cara.

Mejoras después del tratamiento con Factores de Crecimiento

Los resultados de los estudios in vitro y clínicos sugieren que los factores de crecimiento, citocinas, matrikinas o péptidos similares a las matrikinas pueden mejorar la producción de colágeno y otras moléculas de ECM y promover el rejuvenecimiento de la piel. Debido a su pequeño tamaño, las matrikinas y los péptidos similares a las matrikinas ofrecen la promesa de actividades similares al factor de crecimiento con una mejor penetración de la piel. Sin embargo, los datos son limitados. Es necesario evaluar estos productos en ensayos aleatorios bien diseñados para poder sacar conclusiones firmes sobre sus efectos clínicos y mecanismos de acción.

Publicaciones Científicas

Fighting against Skin Aging

Abstract

As the most voluminous organ of the body that is exposed to the outer environment, the skin suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features such as wrinkling, loss of elasticity, laxity, and rough-textured appearance. This aging process is accompanied with phenotypic changes in cutaneous cells as well as structural and functional changes in extracellular matrix components such as collagens and elastin. In this review, we summarize these changes in skin aging, research advances of the molecular mechanisms leading to these changes, and the treatment strategies aimed at preventing or reversing skin aging.

Keywords: skin aging, intrinsic aging, extrinsic aging, extracellular matrix, treatment strategy


Introduction

Skin is the barrier that segregates the body from the outer environment. Besides protecting the body from water loss and microorganism infection, it has an important cosmetic role. Young and beautiful appearance may have a positive influence on people’s social behavior and reproductive status1.

However, aging of organs begins from the time when one is born, and there is no exception for the skin. As the most voluminous organ of the body, the skin shows obvious and visible sign of aging when one becomes older. Therefore, for many people, especially females, a considerable amount of daily expense is occupied by cosmetics and pharmaceuticals attempting to prevent or reverse skin aging2. This vast cosmetic need continually promotes research on skin aging and its treatment.

Cutaneous aging is induced by both intrinsic and extrinsic factors. Intrinsic aging is an inevitable physiological process that results in thin, dry skin, fine wrinkles, and gradual dermal atrophy, while extrinsic aging is engendered by external environment factors such as air pollution, smoking, poor nutrition, and sun exposure, resulting in coarse wrinkles, loss of elasticity, laxity, and rough-textured appearance3,4. Notably, long-term exposure to solar ultraviolet (UV) radiation is the primary factor of extrinsic skin aging and is referred to as photoaging4. In this review, we will summarize the changes during skin aging, research advances of the molecular mechanisms leading to these changes, and treatment strategies.

Continua con la lectura en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047276/

Skin rejuvenation using cosmetic products containing growth factors, cytokines, and matrikines: a review of the literature

Abstract

Skin aging is primarily due to alterations in the dermal extracellular matrix, especially a decrease in collagen I content, fragmentation of collagen fibrils, and accumulation of amorphous elastin material, also known as elastosis. Growth factors and cytokines are included in several cosmetic products intended for skin rejuvenation because of their ability to promote collagen synthesis. Matrikines and matrikine-like peptides offer the advantage of growth factor-like activities but better skin penetration due to their much smaller molecular size. In this review, we summarize the commercially available products containing growth factors, cytokines, and matrikines for which there is evidence that they promote skin rejuvenation.

Keywords: cosmetics, skin, aging, growth factor, cytokine, matrikine


Introduction

Skin aging is a natural process caused by both intrinsic changes and extrinsic damage.1,2 Much of the change occurs in the dermis, which is mostly composed of a dense, collagen-rich extracellular matrix (ECM) that provides structure and support for the skin cells and confers tensile strength and firmness to the skin (Figure 1).1,2 Elastic fibers, which are made up of a cross-linked elastin core within fibrillin-based microfibrils, are key secondary components of the dermis that provide elasticity, resilience, and added tensile strength.3 Important changes also occur in the epidermis, most notably the accumulation of corneocytes, which causes the skin to take on a rough and dull appearance.1,4 In addition, reduced skin vasculature and structural changes to the subcutaneous tissue participate in skin aging.

Continua con la lectura en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108505/